1224100-52-0

Basic information

• Product Name: tert-butyl [3-(cyclobutylamino)-2-oxo-6-phenylpyrazin-1(2H)-yl]acetate
• Synonyms: tert-butyl [3-(cyclobutylamino)-2-oxo-6-phenylpyrazin-1(2H)-yl]acetate
• CAS NO: 1224100-52-0
• Molecular Weight: 355.437
• Mol File: 1224100-52-0.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl [3-(cyclobutylamino)-2-oxo-6-phenylpyrazin-1(2H)-yl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [3-(cyclobutylamino)-2-oxo-6-phenylpyrazin-1(2H)-yl]acetate(1224100-52-0)
• EPA Substance Registry System: tert-butyl [3-(cyclobutylamino)-2-oxo-6-phenylpyrazin-1(2H)-yl]acetate(1224100-52-0)

Safety Data

• Hazardous Substances Data: 1224100-52-0(Hazardous Substances Data)

Upstream product

• 374671-03-1 tert-butyl [6-bromo-3-(cyclobutylamino)-2-oxopyrazin-1(2H)-yl]acetate 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Synthesis of a versatile 2 (1H)-pyrazinone core for the preparation of Tissue Factor-Factor VIIa inhibitors

A new, general synthetic route to 2(1H)-pyrazinones 11 is described. The four-step synthesis is accomplished utilizing a regioselective hydrolysis and N-alkylation. These compounds efficiently undergo metal-catalyzed cross-coupling reactions to install P2 diversity groups in the 6-position, which can be used to refine the SAR of the S2 pocket of the Tissue Factor/Factor VIIa (TF/VIIa) complex.