1224142-46-4Relevant academic research and scientific papers
Palladium catalyzed synthesis of 2-trifluoromethylquinolines through a domino Sonogashira-alkyne carbocyclization process
Chen, Zixian,Zhu, Jiangtao,Xie, Haibo,Li, Shan,Wu, Yongming,Gong, Yuefa
, p. 2145 - 2147 (2010)
A new, rapid and high-yielding method to prepare 3,4-disubstituted 2-trifluoromethylquinolines by a palladium catalyzed tandem Sonogashira-alkyne carbocyclization of β-trifluoromethyl β-enaminoketones with arynes is described. Moderate to excellent yields have been achieved under mild conditions. This reaction can also be expanded to the non-fluorine containing substrates. The reaction mechanism is also discussed. The Royal Society of Chemistry.
