122427-41-2Relevant academic research and scientific papers
Large-Scale Preparation of Pure (+)-(1S,2R,5S)-5-Methyl-2-(1-methyl-1-phenylethyl)cyclohexanol
Buschmann, Helmut,Scharf, Hans-Dieter
, p. 827 - 830 (1988)
A procedure is described for the preparation of (S)-(-)pulegone, (-)-1, starting from (S)-(-)citronellol, (-)-6, in a preparative scale.Compound (-)-1 can easily be converted into (+)-(1S,2R,5S)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexanol: (+)-2 by a procedure described in literature, which was simplified essentially.Now (+)-2 is accessible in larger amounts and thus is available as an efficient chiral auxiliary in stoichiometric asymmetric syntheses.
