1224288-66-7

Basic information

• Product Name: 4-(2,2-dicyanovinylamino)-N-(3-methylisoxazol-5-yl)benzenesulfonamide
• CAS NO: 1224288-66-7
• Molecular Weight: 329.339
• Mol File: 1224288-66-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2,2-dicyanovinylamino)-N-(3-methylisoxazol-5-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2-dicyanovinylamino)-N-(3-methylisoxazol-5-yl)benzenesulfonamide(1224288-66-7)
• EPA Substance Registry System: 4-(2,2-dicyanovinylamino)-N-(3-methylisoxazol-5-yl)benzenesulfonamide(1224288-66-7)

Safety Data

• Hazardous Substances Data: 1224288-66-7(Hazardous Substances Data)

Upstream product

• 17103-52-5 4-amino-N-(3-methyl-1,2-oxazol-5-yl)benzene-1-sulfonamide 
• 122-51-0 orthoformic acid triethyl ester 
• 109-77-3 malononitrile 

Downstream Products

• 1224288-90-7 4-(5-cyano-4-oxo-3-phenyl-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)(3-methylisoxazol-5-yl)benzenesulfonamide 
• 1224288-80-5 N-{4-[(3-amino-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methylamino]phenylsulfonyl}acetamide 

Relevant articles and documents

Synthesis of some new pyrazole and pyrimidine derivatives carrying a sulfonamide moiety of expected antitumor activity and study of the synergistic effect of γ-irradiation

Several novel pyrazole (11-18) and pyrimidine (19-23) derivatives were synthesized starting from different sulfonamides and different active methylenes. The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR and mass spectral data. The obtained compounds were screened as antitumor agents against human tumor cell line. Some of the tested compounds were equipotent while the others were more potent than doxorubicin (CAS 25316-40-9). The synergistic effect with γ-radiation was also studied. ECV·Editio Cantor Verlag, Aulendorf (Germany).