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1224435-88-4

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1224435-88-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1224435-88-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,4,4,3 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1224435-88:
(9*1)+(8*2)+(7*2)+(6*4)+(5*4)+(4*3)+(3*5)+(2*8)+(1*8)=134
134 % 10 = 4
So 1224435-88-4 is a valid CAS Registry Number.

1224435-88-4Relevant articles and documents

Design, synthesis, and preliminary pharmacological evaluation of new imidazolinones as l-DOPA prodrugs

Giorgioni, Gianfabio,Claudi, Francesco,Ruggieri, Sabrina,Ricciutelli, Massimo,Palmieri, Giovanni F.,Stefano, Antonio Di,Sozio, Piera,Cerasa, Laura S.,Chiavaroli, Annalisa,Ferrante, Claudio,Orlando, Giustino,Glennon, Richard A.

, p. 1834 - 1843 (2010)

l-DOPA, the immediate biological precursor of dopamine, is still considered the drug of choice in the treatment of Parkinson's disease. However, therapy with l-DOPA is associated with a number of acute problems. With the aim to increase the bioavailability after oral administration, we designed a multi-protected l-DOPA prodrugs able to release the drug by both spontaneous chemical or enzyme catalyzed hydrolysis. The new compounds have been synthesized and preliminarily evaluated for their water solubility, log P, chemical stability, and enzymatic stability. The results indicate that the incorporation of the amino acidic moiety of l-DOPA into an imidazoline-4-one ring provides prodrugs sufficiently stable to potentially cross unchanged the acidic environment of the stomach, and to be absorbed from the intestine. They also might be able to release l-DOPA in human plasma after enzymatic hydrolysis. The ability of prodrugs 6a-b to increase basal levels of striatal DA, and influence brain neurochemistry associated with dopaminergic activity following oral administration, as well as the radical-scavenging activity against DPPH for compounds 6a-b and 15a are also reported.

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