1224436-75-2Relevant articles and documents
Total Synthesis of Marine Glycosphingolipid Vesparioside B
Gao, Peng-Cheng,Zhu, San-Yong,Cao, Hui,Yang, Jin-Song
, p. 1684 - 1688 (2016)
The first total synthesis of a major component of marine glycolipid vesparioside B (Scheme 1, 1, R1 = n-C22H45, R2 = n-C14H29) has been accomplished through a convergent [4 + 3] coupling strategy. Key steps included stereoselective installment of a set of challenging 1,2-cis-glycoside bonds. A 2-quinolinecarbonyl-assisted α-galactosylation and a novel β-arabinosylation were developed, respectively, to synthesize the α-galactofuranosidic and the β-arabinopyranosidic linkages. Furthermore, a 4,6-O-benzylidene-controlled α-galactopyranosylation reaction allowed the efficient connection of the left tetrasaccharide donor 2 with the right disaccharide lipid acceptor 3, hence leading to the total synthesis of 1.
INKT CELL MODULATORS AND METHODS OF USING THE SAME
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Paragraph 0068; 00156, (2013/06/27)
Disclosed herein are α-galactosylceramide (α-GalCer) analogs and compositions thereof, methods of activating invariant Natural Killer T (iNKT) cells using said analogs, methods of treating diseases by activating iNKT cells using said analogs, and combinat
