1224437-17-5Relevant articles and documents
Synthesis of 5-arylpyrrolo[2,1-c][1,4]benzodiazepines under mild cyclodehydration conditions
Legerén, Loreto,Domínguez, Domingo
experimental part, p. 2718 - 2722 (2010/05/02)
The efficiency of a cyclodehydration reaction leading to benzodiazepinones is markedly improved by N-methylation of the amide link connecting the nucleophile and the electrophile, which is attributed to its favouring both the more reactive E-rotamer and the exit of the leaving group.