1224443-47-3

Basic information

• Product Name: Latanoprost (free acid)-d4
• Synonyms: Latanoprost (free acid)-d4;HNPFPERDNWXAGS-GPPKKVIBSA-N
• CAS NO: 1224443-47-3
• Molecular Formula: C23H30D4O5
• Molecular Weight: 394.537707112
• Mol File: 1224443-47-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Latanoprost (free acid)-d4(CAS DataBase Reference)
• NIST Chemistry Reference: Latanoprost (free acid)-d4(1224443-47-3)
• EPA Substance Registry System: Latanoprost (free acid)-d4(1224443-47-3)

Safety Data

• Hazardous Substances Data: 1224443-47-3(Hazardous Substances Data)

Usage

Description

Latanoprost (free acid)-d4 (Lat-FA-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. It is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC50 value of 3.6 nM for human FP receptors, which is twice the potency of PGF2α and more than 200 times more potent latanoprost. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Uses

Latanoprost Acid-d4 is the labeled analogue of Latanoprost Acid (L177310), a metabolite of Latanoprost. Latanoprost Acid (L177310) is a potent, selective FP prostanoid receptor agonist, a F-series Prostaglandin analog and is 200 times as potent as isopropyl ester form.