1224447-44-2Relevant academic research and scientific papers
Synthesis of arylated benzofurans by regioselective Suzuki-Miyaura cross-coupling reactions of 2,3-dibromobenzofurans- and 2,3,5-tribromobenzofurans
Hussain,Thai Hung,Abbas,Khera,Malik,Patonay,Kelzhanova,Abilov,Villinger,Langer
, p. 497 - 505 (2015/03/30)
Arylated benzofurans were prepared by regioselective Suzuki-Miyaura cross-coupling reactions of 2,3-dibromobenzofuran. The reactions proceeded with very good site-selectivity in favor of the more electron deficient position 2. The Suzuki-Miyaura reactions
Direct arylation of benzo[b]furan and other benzo-fused heterocycles
Dao-Huy, Toan,Haider, Maximilian,Glatz, Fabian,Schnürch, Michael,Mihovilovic, Marko D.
supporting information, p. 8119 - 8125 (2015/01/09)
The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo-fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[b]-furan.
Site-selective Suzuki cross-coupling reactions of 2,3-dibromobenzofuran
Hung, Nguyen Thai,Hussain, Munawar,Malik, Imran,Villinger, Alexander,Langer, Peter
scheme or table, p. 2420 - 2422 (2010/06/21)
The Suzuki-Miyaura reaction of 2,3-dibromobenzofuran with two equivalents of boronic acids gave 2,3-diarylbenzofurans. The reaction with one equivalent of arylboronic acids resulted in site-selective formation of 2-aryl-3-bromobenzofurans. 2,3-Diarylbenzofurans containing two different aryl groups were prepared from 2,3-dibromobenzofuran in a one-pot protocol by sequential addition of two different boronic acids.
