1224447-52-2Relevant academic research and scientific papers
Synthesis of arylated benzofurans by regioselective Suzuki-Miyaura cross-coupling reactions of 2,3-dibromobenzofurans- and 2,3,5-tribromobenzofurans
Hussain,Thai Hung,Abbas,Khera,Malik,Patonay,Kelzhanova,Abilov,Villinger,Langer
, p. 497 - 505 (2015/03/30)
Arylated benzofurans were prepared by regioselective Suzuki-Miyaura cross-coupling reactions of 2,3-dibromobenzofuran. The reactions proceeded with very good site-selectivity in favor of the more electron deficient position 2. The Suzuki-Miyaura reactions
Site-selective Suzuki cross-coupling reactions of 2,3-dibromobenzofuran
Hung, Nguyen Thai,Hussain, Munawar,Malik, Imran,Villinger, Alexander,Langer, Peter
scheme or table, p. 2420 - 2422 (2010/06/21)
The Suzuki-Miyaura reaction of 2,3-dibromobenzofuran with two equivalents of boronic acids gave 2,3-diarylbenzofurans. The reaction with one equivalent of arylboronic acids resulted in site-selective formation of 2-aryl-3-bromobenzofurans. 2,3-Diarylbenzofurans containing two different aryl groups were prepared from 2,3-dibromobenzofuran in a one-pot protocol by sequential addition of two different boronic acids.
MPHT-Promoted bromocyclization of of ortho-substituted arylalkynes: Application to the synthesis of 2-substituted 3-bromobenzofurans and -benzo[b]thiophenes
Jacubert, Maud,Tikad, Abdellatif,Provot, Olivier,Hamze, Abdallah,Brion, Jean-Daniel,Alami, Mouad
experimental part, p. 4492 - 4500 (2010/10/02)
A convenient: and general approach to the synthesis of 2substituted 3-bromobenzofurans and -benzothiophenes was developed. The procedure is based, on the cyclization of orfho-substituted arylalkynes in the presence of N-methylpyrrolidin-2-one hydrotribromide (MPHT) as a soft and easy-tohandle electrophilic brominating reagent. Under mild reaction conditions, MPHT promoted the bromocyclization of various enynes and diynes as well as arylalkynes to give 2substituted 3-bromobenzofurans and -benzothiophenes in. high to excellent: yields. Subsequent: functionalization by palladium-catalyzed coupling reactions at the C-Br bond afforded general access to 2,3-disubstituted benzofurans and benzothiophenes of biological interest.
