1224449-98-2

Upstream product

• 33948-36-6 2-iodocyclohex-2-en-1-one 
• 143360-92-3 2,2,2-Trifluoro-N-[2-(4-phenyl-cyclohex-1-enylethynyl)-phenyl]-acetamide 

Relevant academic research and scientific papers

3-(2-Alken-1-one-2-yl)indoles through the palladium-catalyzed reaction of 2-alkynyltrifluoroacetanilides with cyclic α-iodoenones

α-Iodoenones can be efficiently employed as organic electrophiles in the Pd-catalyzed synthesis of 2,3-disubstituted indoles from 2-alkynyltrifluoroacetanilides. Best results were obtained using the weak ligand As(Ph)3. The methodology reported provides an efficient entry to indoles bearing a 2-alkenon-2-yl moiety linked in the 3-position, that possesses a scarcely reported substitution pattern.