1224495-71-9Relevant academic research and scientific papers
Rational design of potent GSK3β inhibitors with selectivity for Cdk1 and Cdk2
Lesuisse, Dominique,Dutruc-Rosset, Gilles,Tiraboschi, Gilles,Dreyer, Matthias K.,Maignan, Sébastien,Chevalier, Alain,Halley, Frank,Bertrand, Philippe,Burgevin, Marie-Claude,Quarteronet, Dominique,Rooney, Thomas
scheme or table, p. 1985 - 1989 (2010/08/06)
From an HTS hit, a series of potent and selective inhibitors of GSK3β have been designed based on a Cdk2-homology model and with the help of several crystal structures of the compounds within Cdk2.
Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof
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Page/Page column 51-52, (2010/11/30)
The present invention relates to the novel indazole derivatives of general formula (I): in which: R is either O, S or NH; R3 is an alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryl, heterocycle, cycloalkyl, alkenyl, etc. radical; these radicals being optionally substituted with one or more substituents; R4, R5, R6 and R7 are chosen, independently of each other, from the following radicals: hydrogen, halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle, cycloalkyl, alkenyl, etc.; these radicals being optionally substituted with one or more substituents.
