122453-85-4

Usage

Uses

Used in Pharmaceutical Research and Drug Discovery:
2-phenyl-1H-pyrrole-4-carbonitrile is utilized as a key intermediate in the synthesis of various pharmaceutical compounds due to its potential biological activities. Its anti-inflammatory and anticancer properties make it a promising candidate for the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-phenyl-1H-pyrrole-4-carbonitrile serves as a versatile building block for the creation of new organic compounds and materials. Its unique structure and reactivity contribute to the synthesis of a wide range of chemical entities with potential applications in various industries.
Used in Medicinal Chemistry:
2-phenyl-1H-pyrrole-4-carbonitrile is employed as a scaffold in medicinal chemistry for the design and optimization of novel bioactive molecules. Its ability to modulate biological targets and pathways makes it a valuable tool in the discovery of new drugs and therapeutic agents.

Upstream product

• 14476-72-3 2-(2-oxo-2-phenylethyl)malononitrile 
• 31594-51-1 2-phenyl-4-cyano-Δ¹-pyrroline 
• 36635-66-2 α-tosylbenzyl isocyanide 
• 107-13-1 acrylonitrile 

Relevant academic research and scientific papers

An Efficient, Scalable and Eco-friendly Synthesis of 4,5-substituted Pyrrole-3-Carbonitriles by Intramolecular Annulation on Pd/C and HZSM-5

An efficient and eco-friendly protocol for the synthesis of diverse 4,5-substituted 1H-pyrrole-3-carbonitriles has been developed using commercially available HZSM-5 and Pd/C as recyclable heterogeneous catalysts with more excellent yields (up to 98 %) than traditional liquids acids, and successfully applied in the practical synthesis of vonoprazan. The conspicuous features of this protocol are higher product yield, easy work-up, eco-friendly and reusability of catalysts.

PROCESS FOR PRODUCING PYRROLE COMPOUND

The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of produci

4-Substituted 2-phenyl- and 2-phenyl-3-aryl pyrroles by reaction of tosyl benzyl isocyanide (TosBIC) with Michael acceptors

Synthesis of 2-phenyl and 2,3-diphenylpyrroles bearing at the 4 position electronwithdrawing groups by reaction of tosylbenzylisocyanide (TosBIC) with various Michael acceptors was investigated. Sodium hydride and n-butyllithium were used as deprotonating agents for the synthesis of monophenyl and diphenylpyrroles, respectively.

Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof

This invention is directed to certain novel insecticidal, acaricidal and nematicidal arylpyrrole agents and a method for controlling insects, acarids and nematodes therewith. The invention also is directed to a method for protecting growing plants from insect, acarid and nematode attack by applying to said plants or the soil in which they are growing, an insecticidally, acaricidally or nematicidally effective amount of a novel arylpyrrole compound. The present invention further is directed to a method for the preparation of the arylpyrrole compounds.

Method of controlling phytopathogenic fungi

This invention is directed to a method for the control of phytopathogenic fungi by contacting the same with a cyano- or nitroarylpyrrole compound, or by applying said pyrrole compound to the foliage of a plant susceptible to disease caused by said pathogens.

Method of and bait compositions for controlling mollusks

This invention relates to methods of controlling mollusks with arylpyrrole compounds and to bait compositions containing a molluscicidally effective amount of an arylpyrrole compound.