122455-35-0

Upstream product

• 421-83-0 trifluoromethane sulfonyl chloride 
• 1526-17-6 2-fluoro-6-nitrophenol 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 1072930-78-9 [5-(7-fluoro-1-propyl-1H-benzoimidazol-2-yl)-pyridin-2-yl]-(4-methoxy-phenyl)-amine 
• 1072928-96-1 3-fluoro-N-2-propyl-benzene-1,2-diamine 
• 1072928-97-2 (2-fluoro-6-nitro-phenyl)-propyl-amine 
• 122455-36-1 1-Fluoro-3-nitroiodobenzene 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AS INHIBITORS OF KRAS G12C

Provided are heterocyclic compounds as inhibitors of the KRAS G12C and uses thereof. Specifically, provided are the compounds of any of formula I to XI or stereoisomers, enantiomers, atropoisomerics or pharmaceutically acceptable salts thereof. Definition of each group in the formula can be found in the specification for details.

Organic compounds

The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the formula (I): in which the substitutents are as defined in claim 1 and salts, solvates, hydrates and N-oxides thereof.

NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5

The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the Formula (I): in which the substitutents are as defined in claim 1 and and salts, solvates, hydrates and N- oxides thereof.

Compounds and Uses Thereof

This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of anxiety disorders, cognitive disorders, and/or mood disorders.

Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.