1224583-61-2Relevant academic research and scientific papers
Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies
Karuppasamy, Muthukumar,Mahapatra, Manojkumar,Yabanoglu, Samiye,Ucar, Gulberk,Sinha, Barij Nayan,Basu, Arijit,Mishra, Nibha,Sharon, Ashoke,Kulandaivelu, Umasankar,Jayaprakash, Venkatesan
experimental part, p. 1875 - 1881 (2010/05/02)
3,5-Diaryl pyrazolines analogs were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity. The compounds were found reversible and selective towards MAO-A with selectivity index in the magnitude of 103-105. The docking studies were carried out to gain further structural insights of the binding mode and possible interactions with the active site of MAO-A. Interestingly, the theoretical (Ki) values obtained by molecular docking studies were in congruence with their experimental (Ki) values.
