1224587-86-3

Upstream product

• 1224587-89-6 (3aR,6S,6aS)-6-iodomethyl-4-methoxy-2,2-dimethyl-4-phenyltetrahydrofuro[3,4-d][1,3]dioxole 
• 1353779-07-3 C₁₀H₁₇NO₃ 
• 100-58-3 phenylmagnesium bromide 
• 30725-00-9 2,3-O-isopropylidene-D-ribonic-γ-lactone 

Downstream Products

• 1316794-66-7 (R,E)-1-(tert-butyldimethylsilyloxy)-4-{(4R,5S)-5-[(S)-hydroxy(phenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}but-3-en-2-ol 
• 1316794-78-1 tert-butyl {(E)-3-[(3aR,4S,6S,6aS)-2,2-dimethyl-6-phenyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]allyloxy}dimethylsilane 
• 1316794-53-2 {(4R,5R)-5-[(S,E)-4-(tert-butyldimethylsilyloxy)-3-hydroxybut-1-enyl]-2,2-dimethyl-1,3-dioxolan-4-yl}phenylmethanone 
• 1316794-64-5 (S,E)-1-(tert-butyldimethylsilyloxy)-4-{(4R,5S)-5-[(R)-hydroxy(phenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}but-3-en-2-ol 
• 1316794-61-2 (S,E)-1-(tert-butyldimethylsilyloxy)-4-{(4R,5S)-5-[(S)-hydroxy(phenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}but-3-en-2-ol 
• 1316794-59-8 (6R,9R,E)-2,2,3,3,12,12,13,13-octamethyl-4,11-dioxa-3,12-disilatetradec-7-ene-6,9-diol 
• 1316794-58-7 {(4R,5R)-5-[(R,E)-4-(tert-butyldimethylsilyloxy)-3-hydroxybut-1-enyl]-2,2-dimethyl-1,3-dioxolan-4-yl}phenylmethanone 

Relevant academic research and scientific papers

Stereospecificity in the Au-catalysed cyclisation of monoallylic diols. Synthesis of (+)-isoaltholactone

We describe a concise synthesis of (+)-isoaltholactone via a Au-catalysed cyclisation of a monoallylic diol to form the tetrahydrofuranyl ring. Analogous cyclisations show that the stereochemical outcome is dictated by the stereochemistry of the diol substrate.

Aspects of stereocontrol in the L-Selectride reduction of 4-acyl-1,3-dioxolane derivatives

The application of L-Selectride, either alone or in combination with ZnCl2, to aryl ketones 1, 8 and 11 resulted in highly anti-stereoselective reduction. In contrast, lactols 22 and 23 gave a moderate syn-preference using L-Selectride alone an