1224597-07-2Relevant articles and documents
Stille cross-coupling reactions of aryl mesylates and tosylates using a biarylphosphine based catalyst system
Naber, John R.,Fors, Brett P.,Wu, Xiaoxing,Gunn, Jonathon T.,Buchwald, Stephen L.
, p. 1215 - 1226 (2010)
A catalyst system for the Stille cross-coupling reactions of aryl mesylates and tosylates is reported. Using the combination of Pd(OAc)2, XPhos, and CsF in t-BuOH an array of aryl and heteroaryl sulfonates were successfully employed in these reactions. Morever, heteroarylstannanes, such as furyl, thienyl, and N-methylpyrrolyl, which are often prone to decomposition, were efficiently coupled under these conditions. Ortho-substitution on the stannane coupling partner was well tolerated; however, the presence of ortho substituents on the aryl sulfonates greatly reduced the efficiency of these reactions.
