1224600-12-7Relevant articles and documents
Amide-based inhibitors of p38α MAP kinase. Part 2: Design, synthesis and SAR of potent N-pyrimidyl amides
Tester, Richland,Tan, Xuefei,Luedtke, Gregory R.,Nashashibi, Imad,Schinzel, Kurt,Liang, Weiling,Jung, Joon,Dugar, Sundeep,Liclican, Albert,Tabora, Jocelyn,Levy, Daniel E.,Do, Steven
scheme or table, p. 2560 - 2563 (2010/07/03)
Optimization of a tri-substituted N-pyridyl amide led to the discovery of a new class of potent N-pyrimidyl amide based p38α MAP kinase inhibitors. Initial SAR studies led to the identification of 5-dihydrofuran as an optimal hydrophobic group. Additional
