1224606-06-7

Basic information

• Product Name: DLin-M-C3-DMA
• Synonyms: DLin-M-C3-DMA
• CAS NO: 1224606-06-7
• Molecular Formula: C43H79NO2
• Molecular Weight: 642.09
• Mol File: 1224606-06-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 670.2±43.0 °C(Predicted)
• Appearance: /
• Density: 0.886±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in Ethanol, DMSO, DMF
• PKA: 9.37±0.28(Predicted)
• CAS DataBase Reference: DLin-M-C3-DMA(CAS DataBase Reference)
• NIST Chemistry Reference: DLin-M-C3-DMA(1224606-06-7)
• EPA Substance Registry System: DLin-M-C3-DMA(1224606-06-7)

Safety Data

• Hazardous Substances Data: 1224606-06-7(Hazardous Substances Data)

Usage

Description

D-Lin-MC3-DMA (MC3, DLin-MC3-DMA) is a potent and ionizable cationic lipid. D-Lin-MC3-DMA is used for delivery of siRNA in vivo. DLin-MC3-DMA, or (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate , is one of the most utilized cationic lipids that is used for making Lipid Nano-Particles (LNPs). These lipids, can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into the cytoplasm and represent the most advanced delivery platforms for systemic administration of active molecules.

Biological Activity

DLin-MC3-DMA is an ionizable lipid used in combination with other lipids for encapsulation of RNA and DNA into lipid nanoparticles (LNPs). Administration of DLin-MC3-DMA based LNPs have delivered siRNA and reduced Factor VII levels in mice. Delivery of BCR-ABL siRNA reduced leukemic burden in a mouse model of chronic myeloid leukemia (CML).