1224617-70-2Relevant academic research and scientific papers
Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures
Castonguay, Annie,Wilson, Eleanor,Al-Hajaj, Noura,Petitjean, Laurene,Paoletti, Julie,Maysinger, Dusica,Kakkar, Ashok
, p. 12146 - 12148 (2011/12/15)
A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated at the periphery of the thermosensitive dendrimer formulations undergoes slow and sustained release at 37-42 °C, and rescues the cells from oxidative stress and a pro-inflammatory endotoxic agent. The Royal Society of Chemistry 2011.
Combined CuI-catalysed alkyne-azide cycloaddition and furan-maleimide Diels-Alder "click" chemistry approach to thermoresponsive dendrimers
Vieyres, Arnaud,Lam, Tina,Gillet, Renaud,Franc, Gregory,Castonguay, Annie,Kakkar, Ashok
scheme or table, p. 1875 - 1877 (2010/06/16)
A divergent dendrimer construction methodology that employs Cu I-catalysed alkyne-azide cycloaddition (CuAAC) and furan-maleimide Diels-Alder (DA) "click" chemistry in a layer-by-layer fashion, is described. This synergisitic approach yields dendrimers that undergo thermal disassembly via a retro-DA reaction. The Royal Society of Chemistry 2010.
