1224629-12-2Relevant academic research and scientific papers
Synthesis and evaluation of a library of 2,5-bisdiamino-benzoquinone derivatives as probes to modulate protein-protein interactions in prions
Tran, Hoang Ngoc Ai,Bongarzone, Salvatore,Carloni, Paolo,Legname, Giuseppe,Bolognesi, Maria Laura
scheme or table, p. 1866 - 1868 (2010/07/04)
A small library combining two different benzoquinone cores with seven (l) amino acid methyl esters (alanine, Nω-nitro-arginine, Nε-BOC-lysine, isoleucine, methionine, phenylalanine and tryptophan) was prepared and tested for prion replication inhibition in ScGT1 cells. The most potent hit, 6a, displayed an EC50 value of 0.87 μM, which is very close to that of quinacrine (0.4 μM).
