1224632-19-2Relevant academic research and scientific papers
Synthesis of unnatural selenocystines and β-aminodiselenides via regioselective ring-opening of sulfamidates using a sequential, one-pot, multistep strategy
Rashid Baig, Nasir Baig,Chandrakala,Sudhir, V. Sai,Chandrasekaran, Srinivasan
, p. 2910 - 2921 (2010)
A variety of N-alkyl-β-aminodiselenides have been synthesized in high yield from sulfamidates under mild reaction conditions using potassium selenocyanate and benzyltriethylammonium tetrathiomolybdate ([BnNEt 3]2MoS4) in a sequential, one-pot, multistep reaction. The tolerance of multifarious protecting groups under the reaction conditions is discussed. The methodology was successfully extended to the synthesis of selenocystine, 3,3′-dialkylselenocystine, and 3,3′-diphenylisoselenocystine and their direct incorporation into peptides.
