1224635-46-4Relevant academic research and scientific papers
Gold-catalyzed intramolecular alkyne cycloisomerization cascade: Direct synthesis of aryl-annulated[a]carbazoles from aniline-substituted diethynylarenes
Hirano, Kimio,Inaba, Yusuke,Watanabe, Toshiaki,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
, p. 368 - 372 (2010)
Aniline-substituted diethynylarenes, which are readily synthesized through Sonogashira coupling reactions from commercially available 1,2-dihaloarenes, directly produce aryl- and heteroaryl-annulated [a]carbazoles by the gold-catalyzed intramolecular casc
Direct synthesis of fused indoles by gold-catalyzed cascade cyclization of diynes
Hirano, Kimio,Inaba, Yusuke,Takahashi, Naoya,Shimano, Masanao,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
experimental part, p. 1212 - 1227 (2011/04/25)
A direct, concise, and atom-economical synthetic method for the generation of fused indoles, using a gold-catalyzed cascade cyclization of diynes, has been developed. The reaction gave various fused indoles, such as aryl-annulated[a]carbazoles, dihydrobenzo[g]indoles, and azepino-or oxepinoindole derivatives in good to excellent yields, through an intramolecular cascade 5-endo-dig hydroamination followed by a 6-or 7-endo-dig cycloisomerization, without producing theoretical byproduct. Three of the resulting indoles exhibited potent antifungal activities against T. mentagrophytes and T. rubrum, demonstrating the practical application of the described cascade reaction for drug discovery.(Figure Presented)
