1224702-05-9

Basic information

• Product Name: 7-phenyl-2-phenylamino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-carbamoyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-amide
• CAS NO: 1224702-05-9
• Molecular Weight: 508.604
• Mol File: 1224702-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-phenyl-2-phenylamino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-carbamoyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-phenyl-2-phenylamino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-carbamoyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-amide(1224702-05-9)
• EPA Substance Registry System: 7-phenyl-2-phenylamino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-carbamoyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-amide(1224702-05-9)

Safety Data

• Hazardous Substances Data: 1224702-05-9(Hazardous Substances Data)

Upstream product

• 1224701-98-7 5-amino-3-phenylamino-1H-pyrazole-4-carboxylic acid (3-carbamoyl-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl)-amide 
• 886-06-6 1-phenyl-3-piperidino-propan-1-one; hydrochloride 

Relevant articles and documents

Synthesis and antimicrobial activities of some new thiazole and pyrazole derivatives based on 4,5,6,7-tetrahydrobenzothiophene moiety

2-(5-oxothiazolidinone)-cyanoacetamido derivative 3 was prepared in two steps by reaction of 2-(2-cyano-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide (1) with phenyl isothiocyanate and chloroacetyl chloride, which diazocoupled with p-tolyldiazonium chloride in pyridine to afford the corresponding hydrazono derivative 4. Also, condensation of 3 with p-anisaldehyde gave the corresponding arylidine derivative 5. Treatment of 2 with dimethyl sulfate afforded the ketene N,S-acetal 9 which give 5-amino pyrazole derivative 10 upon treatment with hydrazine hydrate. Compound 10 was used as key intermediate for synthesis of pyrazolo[5,1-c][1,2,4]triazine 13a, b, pyrazolo[5,1-a]pyrimidine 14-17 and pyrolo pyrazole 18 derivatives. Finally, condensation of 1 with DMF-DMA afforded the corresponding acryloamide derivative 19, which afforded the corresponding pyrazole derivative 20 upon heating with hydrazine hydrate. All new synthesized compounds were evaluated as antimicrobial agents; some of them exhibited promising activities.