1224705-20-7Relevant academic research and scientific papers
Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase
Ducray, Richard,Simpson, Iain,Jung, Frederic H.,Nissink, J. Willem M.,Kenny, Peter W.,Fitzek, Martina,Walker, Graeme E.,Ward, Lara T.,Hudson, Kevin
, p. 4698 - 4701 (2011)
We disclose a novel series of insulin-like growth factor-1 receptor kinase inhibitors based on the 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridine scaffold. The influence on the inhibitory activity of substitution on the imidazopyridine and at the C5 position of the pyrimidine is discussed. In the course of this optimization, we discovered a potent and selective inhibitor with suitable pharmacokinetics for oral administration.
NOVEL COMPOUNDS 515
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Page/Page column 108, (2010/05/13)
There is provided novel pyrimidine derivatives of formula (I) or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy
