1224720-20-0Relevant articles and documents
Design, synthesis and evaluation of (E)-α-benzylthio chalcones as novel inhibitors of BCR-ABL kinase
Reddy, M.V. Ramana,Pallela, Venkat R.,Cosenza, Stephen C.,Mallireddigari, Muralidhar R.,Patti, Revathi,Bonagura, Marie,Truongcao, May,Akula, Balaiah,Jatiani, Shashidhar S.,Reddy, E. Premkumar
experimental part, p. 2317 - 2326 (2010/05/17)
Novel (E)-α-benzylthio chalcones are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (comparable to imatinib, the reference compound) of BCR-ABL phosphorylation in leukemic K562 cells, known to express high levels of BCR-ABL. The ability of such compounds to significantly inhibit K562 cell proliferation suggests that this scaffold could be a promising lead for the development of anticancer agents that are able to block BCR-ABL phosphorylation in leukemic cells.
