1224724-62-2Relevant academic research and scientific papers
Iodoalkene-based approach towards carboxamides of biological importance: aminocarbonylation of 2-iodobornene and 3-iodo-2- quinuclidene
Horvath, Laszlo,Petz, Andrea,Kollar, Laszlo
, p. 54 - 60 (2010)
The palladium-catalysed aminocarbonylation of 2-iodobornene and 3-iodo-2-quinuclidene, possessing iodo alkene functionality, resulted in the high-yielding synthesis of the corresponding carboxamide derivatives. The substrates were synthesised from camphor and 3-quinuclidone, respectively, via their hydrazones. The chemoselective homogeneous carbonylation reaction of synthetic value was carried out under mild reaction conditions. While the carbonylation of the 2- iodobornene was found to be a facile reaction with yields of synthetic interest, its isomer, 1-iodocamphene, formed in Wagner-Meervein rearrangement, remained intact under the same reaction conditions.
