1224733-53-2Relevant academic research and scientific papers
Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists
Morriello, Gregori J.,Mills, Sander G.,Johnson, Tricia,Reibarkh, Mikhail,Chicchi, Gary,DeMartino, Julie,Kurtz, Marc,Davies,Tsao,Zheng, Song,Tong, Xinchun,Carlson, Emma,Townson, Karen,Tattersall,Wheeldon, Alan,Boyce, Susan,Collinson, Neil,Rupniak, Nadia,Moore, Stephen,DeVita, Robert J.
scheme or table, p. 2007 - 2012 (2010/09/15)
Previous work on human NK1 (hNK1) antagonists in which the core of the structure is a 5,5-fused pyrrolizinone has been disclosed. The structural-activity-relationship studies on simple α- and β-substituted compounds of this series pr
