122483-63-0Relevant academic research and scientific papers
Simple grinding-induced reactions of 2-aminobenzyl alcohol and benzaldehyde derivatives, a rapid synthetic route to 3,1-benzoxazines
Masesane, Ishmael B.,Muriithi, Eva,Tabane, Tebogo H.
, p. 301 - 304 (2014)
The grinding-induced reactions of 2-aminobenzyl alcohol and benzaldehyde derivatives in the presence of 30 mol% of acetic acid to give 3,1-benzoxazines are described. The reactions were performed at room temperature affording 3,1-benzoxazines in yields above 95% and high purity when benzaldehyde and its chloro and nitro derivatives were used.
Synthesis of 3,1-benzoxazines and tetrahydroquinazolines from o-aminobenzyl alcohol and o-aminobenzyl amine - Semi-empirical MO calculations
Lessel
, p. 329 - 336 (2007/10/02)
o-Aminobenzyl alcohol (4) reacts with aldehydes and ketones to the 3,1-benzoxazines 20a/b and 22a/b, whereas the enamine derivatives 24a-c are formed from β-diketones. The isosteric o-amino-benzylamine (1) gives tetrahydroquinazolines 11a/b and 14b as het
Ring-Chain Tautomerism in 1,3-Oxazines
Fueloep, Ferenc,Pihlaja, Kalevi,Mattinen, Jorma,Bernath, Gabor
, p. 3821 - 3825 (2007/10/02)
A comparative study on the ring-chain tautomerism of 49 2-(substituted-phenyl) tetrahydro-1,3-oxazines of seven different types, namely, tetrahydro-1,3-oxazines 3,r-8a,c-2,c-4a- and r-8a,c-2,t-4a-1,3-perhydrobenzoxazines 5 and 7,r-8a,c-2,c-4- and r-8a,c-2,t-4a-1,3-perhydrobenzoxazines 9 and 11, 3,4-dihydro-2H-1,3-benzoxazines 12, and 1,2-dihydro-4H-3,1-benzoxazines 13, pointed out that in all cases the equilibria can be described with a simple equation, log Kx = (0.76 +/- 0.04)?+ + logKX=H where Kx = /(X/H).A factor c illustrating the sum of ster ic and electronic effects of substituents at C-4,C-5, and C-6 has also been introduced
