1224945-44-1

Basic information

• Product Name: tert-butyl 2-(2-bromophenyl) pyrrolidine-1-carboxylate
• Synonyms: tert-butyl 2-(2-bromophenyl) pyrrolidine-1-carboxylate
• CAS NO: 1224945-44-1
• Molecular Weight: 326.233
• Mol File: 1224945-44-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-(2-bromophenyl) pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-(2-bromophenyl) pyrrolidine-1-carboxylate(1224945-44-1)
• EPA Substance Registry System: tert-butyl 2-(2-bromophenyl) pyrrolidine-1-carboxylate(1224945-44-1)

Safety Data

• Hazardous Substances Data: 1224945-44-1(Hazardous Substances Data)

Upstream product

• 116861-31-5 tert-butyl N-(3-chloropropyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1311994-51-0 N-Boc-(2-bromobenzyl)-(3-chloropropyl)amine 
• 129540-24-5 2-(2-bromophenyl)pyrrolidine 

Downstream Products

• 1311994-64-5 C₂₇H₂₆N₂O₄S 
• 1311994-59-8 ethyl 1-(benzenesulfonyl)-3-{2-[1-(tert-butylcarbonyl)pyrrolidin]phenyl}-1H-indole-2-carboxylate 
• 1311994-55-4 C₂₁H₃₂BNO₄ 

Relevant articles and documents

1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES

The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

Bcl-2 INHIBITORS

Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

(PYRROLIDIN-2-YL)PHENYL DERIVATIVES

The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyloxy; R2 is H, (C