1224969-11-2Relevant academic research and scientific papers
Straightforward stereoselective synthesis of polyfunctionalised cyclohexenols using a multicomponent approach
Basso, Andrea,Banfi, Luca,Guanti, Giuseppe,Riva, Renata
experimental part, p. 2390 - 2397 (2010/06/16)
An intramolecular Ugi 5-centre-4-component reaction (U-5C-4CR) followed by a palladium-catalysed ring-opening has been employed to transform oxabicycloheptene-based β-amino acids into two families of regioisomeric polyfunctionalised cyclohexenols. The whole process is completely stereoselective and enantiomerically pure products are obtained in high overall yields.
Identification of lead compounds as antagonists of protein Bcl-x L with a diversity-oriented multidisciplinary approach
Di Micco, Simone,Vitale, Romina,Pellecchia, Maurizio,Rega, Michele F.,Riva, Renata,Basso, Andrea,Bifulco, Giuseppe
experimental part, p. 7856 - 7867 (2011/02/21)
We report on the use of a diversity oriented synthesis (DOS) approach that resulted in the generation of a set of libraries of compounds presenting novel structural cores. These chemical cores have been employed to design potential antagonists of the anti
