1224979-07-0

Basic information

• Product Name: C₂₃H₁₇N₃O₂
• CAS NO: 1224979-07-0
• Molecular Weight: 367.407
• Mol File: 1224979-07-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₇N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₇N₃O₂(1224979-07-0)
• EPA Substance Registry System: C₂₃H₁₇N₃O₂(1224979-07-0)

Safety Data

• Hazardous Substances Data: 1224979-07-0(Hazardous Substances Data)

Upstream product

• 1198277-81-4 1-methyl-4-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 161216-29-1 4-pivalamidobenzofuranone 

Relevant articles and documents

4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)

A series of 5-ureidobenzofuranones was discovered as potent and selective inhibitors of mTOR with good cellular activity. Molecular modeling studies revealed several hydrogen bond interactions of the ureido group with the enzyme at the ATP-binding site. Furthermore, modeling showed that the ureido group is best situated at C-5 of the benzofuranone. Syntheses of 4-ureido and 5-ureidobenzofuranones are presented.