1225013-22-8Relevant articles and documents
Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: Development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice
Ishikawa, Makoto,Shinei, Rie,Yokoyama, Fumikazu,Yamauchi, Miki,Oyama, Masayo,Okuma, Kunihiro,Nagayama, Takako,Kato, Kazuhiko,Kakui, Nobukazu,Sato, Yasuo
supporting information; experimental part, p. 3840 - 3844 (2010/08/06)
The terminal nitrogen atom of histamine was modified with lipophilic substituents to investigate the Structure-activity relationship of histamine type 3 receptor (H3R) agonists. The introduction of an alkylated benzene rings maintained or increased the H3