1225014-65-2Relevant academic research and scientific papers
Development of highly sensitive fluorescent probes for detection of intracellular copper(I) in living systems
Taki, Masayasu,Iyoshi, Shohei,Ojida, Akio,Hamachi, Itaru,Yamamoto, Yukio
, p. 5938 - 5939 (2010)
We describe here the new copper-selective fluorescent probes FluTPA1 and FluTPA2, in which the tetradentate ligand tris[(2-pyridyl)methyl]amine (TPA) is connected to a reduced form of a fluorescein platform through a benzyl ether linkage. These probes selectively react with copper ions in the presence of submillimolar glutathione and emit intense green fluorescence from the reaction product, O-methylfluorescein. Confocal images of live cells further show that FluTPA2 is membrane-permeable and allows visualization of CuI present in living cells.
