1225039-46-2

Basic information

• Product Name: C₂₂H₃₂⁽²⁾H₂O₅Si
• Synonyms: C₂₂H₃₂⁽²⁾H₂O₅Si
• CAS NO: 1225039-46-2
• Molecular Weight: 408.579
• Mol File: 1225039-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₃₂⁽²⁾H₂O₅Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₃₂⁽²⁾H₂O₅Si(1225039-46-2)
• EPA Substance Registry System: C₂₂H₃₂⁽²⁾H₂O₅Si(1225039-46-2)

Safety Data

• Hazardous Substances Data: 1225039-46-2(Hazardous Substances Data)

Upstream product

• 1225039-45-1 C₁₁H₂₂⁽²⁾H₂O₄SSi 
• 49769-78-0 2-benzyl-malonic acid dimethyl ester 

Downstream Products

• 1225039-47-3 C₁₅H₁₄⁽²⁾H₂O₄ 

Relevant articles and documents

Mechanistic investigation of the palladium-catalyzed decarboxylative cyclization of γ-methylidene-δ-valerolactones with isocyanates: Kinetic studies and origin of the site selectivity in the nucleophilic attack at a (π-allyl)palladium

Mechanistic studies for the palladium-catalyzed decarboxylative cyclization reactions of γ-methylidene-δ-valerolactones 1 with isocyanates 2 are described. The reactions can be effectively catalyzed by palladium triarylphosphine complexes to give piperidones 3 and/or azaspiro[2.4]heptanones 4. Through kinetic studies using NMR spectroscopy, it has been determined that the oxidative addition of lactones 1 to palladium(0) is the turnover-limiting step of the catalytic cycle. By changes in the electronic properties of the triarylphosphine ligands, the product distribution between 3 and 4 can be easily controlled, and an explanation for the origin of this selectivity is provided. The selectivity between 3 and 4 is also influenced by the nature of the nitrogen substituent on isocyanates 2, and more electron-rich substituents tend to give higher selectivity toward azaspiro[2.4]heptanones 4. These studies represent the first systematic investigation into the selectivity between terminal attack and central attack at (π-allyl)palladium species by nitrogen-based nucleophiles.