1225049-48-8

Basic information

• Product Name: (R)-1-(4-(4-morpholinylphenyl))ethan-1-ol
• Synonyms: (R)-1-(4-(4-morpholinylphenyl))ethan-1-ol
• CAS NO: 1225049-48-8
• Molecular Weight: 207.272
• Mol File: 1225049-48-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-1-(4-(4-morpholinylphenyl))ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-(4-morpholinylphenyl))ethan-1-ol(1225049-48-8)
• EPA Substance Registry System: (R)-1-(4-(4-morpholinylphenyl))ethan-1-ol(1225049-48-8)

Safety Data

• Hazardous Substances Data: 1225049-48-8(Hazardous Substances Data)

Usage

General Description

(R)-1-(4-(4-morpholinylphenyl))ethan-1-ol, also known as N-(4-(4-morpholinophenyl)ethyl)ethan-1-amine, is a chemical compound with the molecular formula C15H21NO2. It is a chiral molecule with a stereocenter and belongs to the class of phenylethanolamines. (R)-1-(4-(4-morpholinylphenyl))ethan-1-ol is used in the synthesis of pharmaceuticals and organic compounds due to its potential biological activity and pharmacological properties. It may also be used as a reagent in chemical research and analysis. Additionally, (R)-1-(4-(4-morpholinylphenyl))ethan-1-ol has been studied for its potential in the treatment of various medical conditions and diseases. However, its exact applications and uses may vary depending on the specific context and industry.

Upstream product

• 39910-98-0 4-morpholinoacetophenone 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of (Hetero)arylketones with Tethered Rh(III)-N-(p-Tolylsulfonyl)-1,2-diphenylethylene-1,2-diamine Complexes: Scope and Limitations

A series of new tethered Rh(III)/Cp? complexes containing the N-(p-tolylsulfonyl)-1,2-diphenylethylene-1,2-diamine ligand have been prepared, characterized, and evaluated in the asymmetric transfer hydrogenation (ATH) of a wide range of (hetero)aryl ketones. The reaction was performed under mild conditions with the formic acid/triethylamine (5:2) system as the hydrogen source and provided enantiomerically enriched alcohols with good yields and high to excellent enantioselectivities. Although the nature of the substituents on the phenyl tethering ring did not alter the stereochemical outcome of the reaction, complexes bearing electron-donating groups exhibited a higher catalytic activity than those having electron-withdrawing groups. A scale-up of the ATH of 4-chromanone to the gram scale quantitatively delivered the reduced product with excellent enantioselectivity, demonstrating the potential usefulness of these new complexes.

RETRACTED ARTICLE: The Manganese(I)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones: Disclosing the Macrocylic Privilege

The bis(carbonyl) manganese(I) complex [Mn(CO)2(1)]Br (2) with a chiral (NH)2P2 macrocyclic ligand (1) catalyzes the asymmetric transfer hydrogenation of polar double bonds with 2-propanol as the hydrogen source. Ketones (43 substrates) are reduced to alcohols in high yields (up to >99 %) and with excellent enantioselectivities (90–99 % ee). A stereochemical model based on attractive CH–π interactions is proposed.

Asymmetric Reduction of Electron-Rich Ketones with Tethered Ru(II)/TsDPEN Catalysts Using Formic Acid/Triethylamine or Aqueous Sodium Formate

The asymmetric transfer hydrogenation (ATH) of ketones under aqueous conditions using tethered Ru(II)/6-arene/diamine catalysts is described, as is the ATH of electron-rich substrates containing amine and methoxy groups on the aromatic rings. Although such substrates are traditionally challenging ones for ATH, the tethered catalysts work very efficiently. In the case of amino-substituted ketones, aqueous conditions give excellent results; however, for methoxy-substituted substrates, the more established formic acid/triethylamine system gives superior results.