1225209-52-8

Basic information

• Product Name: C₅₀H₅₂ClN₄O₈S⁽¹⁺⁾*ClH*I^(1-)
• Synonyms: C₅₀H₅₂ClN₄O₈S⁽¹⁺⁾*ClH*I^(1-)
• CAS NO: 1225209-52-8
• Molecular Weight: 1067.87
• Mol File: 1225209-52-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₅₀H₅₂ClN₄O₈S⁽¹⁺⁾*ClH*I^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₀H₅₂ClN₄O₈S⁽¹⁺⁾*ClH*I^(1-)(1225209-52-8)
• EPA Substance Registry System: C₅₀H₅₂ClN₄O₈S⁽¹⁺⁾*ClH*I^(1-)(1225209-52-8)

Safety Data

• Hazardous Substances Data: 1225209-52-8(Hazardous Substances Data)

Upstream product

• 1225210-44-5 C₆₉H₆₆ClN₄O₈S⁽¹⁺⁾*I^(1-) 

Downstream Products

• 1345689-71-5 C₅₈H₅₈ClN₄O₁₂S₂⁽¹⁺⁾*I^(1-) 
• 1345689-70-4 C₆₅H₆₇ClN₇O₁₂S⁽¹⁺⁾*I^(1-) 
• 1345689-74-8 C₆₀H₆₄ClN₆O₁₁S₂⁽¹⁺⁾*I^(1-) 

Relevant articles and documents

Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship

The structure-activity relationship (SAR) for a novel series of catechol conjugated siderophore cephalosporins is described with their in vitro activities against multi-drug resistant Gram-negative pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia and Enterobacteriaceae. Cefiderocol (3) was one of the best molecules which displayed well-balanced and potent activities against multi-drug resistant Gram-negative pathogens including carbapenem resistant bacteria among the prepared compounds with the modified C-7 side chain and the modified C-3 side chain. Cefiderocol (3) is a highly promising parenteral cephalosporin for the treatment of multi-drug resistant Gram-negative infection.