1225322-54-2

Upstream product

• 1379154-54-7 6-bromo-1-methylquinoxaline-2(1H)-one 
• 2926-29-6 Langlois reagent 

Relevant academic research and scientific papers

Visible Light-Induced Photocatalytic C?H Perfluoroalkylation of Quinoxalinones under Aerobic Oxidation Condition

An efficient approach using a photocatalytic strategy for C?H perfluoroalkylation of quinoxalinones under aerobic oxidation condition has been developed. Such transformation employs readily available sodium perfluoroalkanesulfinates as perfluoroalkylation reagents and demonstrates good functional group compatibility, affording corresponding products in moderate to good yields. Compared with previous procedures, this protocol uses oxygen as oxidant, and avoids the use of external additive. A radical mechanism is involved in this perfluoroalkylation reaction. (Figure presented.).

Direct C?H Trifluoromethylation of Quinoxalin-2(1H)-ones under Transition-Metal-Free Conditions

Disclosed herein is a direct C?H trifluoromethylation of quinoxalin-2(1H)-ones with sodium trifluoromethanesulfinate. This protocol affords a series of 3-trifluoromethylquinoxalin-2(1H)-one derivatives in moderate to excellent yields under transition-metal-free conditions. The present methodology features utilization of the inexpensive trifluoromethyl source without transition-metal-catalysts, mild reaction conditions and high functional group tolerance, which promises a convenient and efficient access to pharmaceutically interesting quinoxalinones. (Figure presented.).

3-trifluoromethyl quinoxalinone compound preparation method

The invention discloses a 3-trifluoromethyl quinoxalinone compound preparation method which comprises the following steps of in an inert gas atmosphere, adding a quinoxalinone compound, sodium trifluoromethanesulfinate and an oxidant in a solvent, performing reaction for 6-18 h at the temperature of 0-75 DEG C, and performing column chromatography separation and purification to obtain 3-trifluoromethyl substituted quinoxalinone compound. The 3-trifluoromethyl quinoxalinone compound preparation method provided by the invention is low in reagent cost, mild in reaction condition and simple in aftertreatment and is suitable for industrial production.