1225326-91-9Relevant academic research and scientific papers
Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors
Mascitti, Vincent,Robinson, Ralph P.,Préville, Cathy,Thuma, Benjamin A.,Carr, Christopher L.,Reese, Matthew R.,Maguire, Robert J.,Leininger, Michael T.,Lowe, André,Steppan, Claire M.
scheme or table, p. 1880 - 1883 (2010/09/07)
Several syntheses of C-5-spirocycle-containing C-glycosides are discussed. A multigram-scale synthesis capitalizing on a one-pot aldol-Cannizzaro sequence is described. Spiro oxetane formation using an unprotected penta-ol C-glycoside as substrate is also exemplified. Functional assessment of these compounds for potency and selectivity was evaluated at human SGLT2 and SGLT1.
