1225339-85-4Relevant academic research and scientific papers
Synthesis of the ABC ring fragment of brevisin, a new dinoflagellate polycyclic ether
Ohtani, Naohito,Tsutsumi, Ryosuke,Kuranaga, Takefumi,Shirai, Tomohiro,Wright, Jeffrey L.C.,Baden, Daniel G.,Satake, Masayuki,Tachibana, Kazuo
scheme or table, p. 825 - 830 (2010/10/03)
A polycyclic ether, brevisin was isolated from the red-tide dinoflagellate Karenia brevis. Its unique skeletal structure consists of two separate tricyclic ether assemblies connected by a methylene bridge. The ABC ring fragment of brevisin was synthesized
An improved synthesis of (-)-brevisamide, a marine monocyclic ether amide of dinoflagellate origin
Tsutsumi, Ryosuke,Kuranaga, Takefumi,Wright, Jeffrey L.C.,Baden, Daniel G.,Ito, Emiko,Satake, Masayuki,Tachibana, Kazuo
scheme or table, p. 6775 - 6782 (2010/10/02)
An improved synthesis of (-)-brevisamide a marine cyclic ether isolated from the red-tide dinoflagellate Karenia brevis was achieved. The ether ring portion was constructed from an unsaturated lactone, which was prepared enantioselectively via an Evans aldol reaction and one-pot lactonization in the presence of excessive base after an Ando reaction. The ether ring and a dienol side chain fragment were connected via Suzuki-Miyaura coupling.
