1225375-82-5Relevant academic research and scientific papers
Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines
Sun, Hongnan,Huang, Binbin,Lin, Run,Yang, Chao,Xia, Wujiong
, p. 524 - 529 (2015/06/08)
The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type ring opening followed by cyclization of the resulting haloalkoxy amine.
Syntheses of chiral β- And γ-amino ethers, morpholines, and their homologues via nucleophilic ring-opening of chiral activated aziridines and azetidines
Ghorai, Manas K.,Shukla, Dipti,Bhattacharyya, Aditya
, p. 3740 - 3753 (2012/06/18)
Figure Persented: Lewis acid catalyzed quaternary ammonium salt mediated highly regioselective ring-opening of chiral activated aziridines and azetidines with alcohols to nonracemic β- and γ-amino ethers has been developed. The reaction mainly proceeds vi
Enantioselective chemoenzymatic synthesis of cis- and trans -2,5-disubstituted morpholines
Ritzen, Bas,Hoekman, Steven,Verdasco, Elena Duran,Van Delft, Floris L.,Rutjes, Floris P. J. T.
supporting information; experimental part, p. 3461 - 3464 (2010/08/19)
A versatile synthesis of enantiomerically pure cis- and trans-2,5-disubstituted morpholines is described. Hydroxynitrile lyase-mediated cyanide addition onto aldehydes provided cyanohydrins in virtually quantitative yield and excellent enantioselectivity.
Enantioselective syntheses of morpholines and their homologues via S N2-type ring opening of aziridines and azetidines with haloalcohols
Ghorai, Manas K.,Shukla, Dipti,Das, Kalpataru
scheme or table, p. 7013 - 7022 (2009/12/22)
(Chemical Equation Presented) A highly regio- and stereoselective strategy for the syntheses in high yield and enantioselectivity of a variety of substituted nonracemic morpholines and their homologues is described. The reaction proceeds via an SN2-type ring opening of activated aziridines and azetidines by suitable halogenated alcohols in the presence of Lewis acid followed by base-mediated intramolecular ring closure of the resulting haloalkoxy amine.
