1225376-11-3Relevant articles and documents
Rhodotorula minuta-mediated bioreduction of 1,2-diketones
Monsalve, Leandro N.,Cerrutti, Patricia,Galvagno, Miguel A.,Baldessari, Alicia
, p. 137 - 143 (2010)
The reduction of cyclic and acyclic 1,2-diketones was investigated by employing whole cells of the yeast Rhodotorula minuta as biocatalyst. The reactions showed a variable degree of regio- and enantioselectivity depending on the nature of the substrate. In the case of cyclic diketones, the reduction afforded a mixture of diastereomeric diols only. The reduction of acyclic diketones allowed production of both the hydroxy ketone and the diol, in a two-step reaction. The first step was highly regio- and stereoselective, affording the hydroxy ketone of (S)-configuration with high enantiomeric excess. After longer reaction times the corresponding (S,S)-diols were obtained in high yield and diastereomeric excess.
