1225384-88-2Relevant articles and documents
Total synthesis and configurational validation of (+)-phorbaside A
Paterson, Ian,Paquet, Tanya
supporting information; experimental part, p. 2158 - 2161 (2010/08/06)
Figure presented The configurational assignment of the cytotoxic marine macrolide phorbaside A has been verified by the stereodefined synthesis of the proposed structure 1 and its (18S,19R)-diastereomer 3, followed by correlation using circular dichroism spectroscopy. This first total synthesis, which proceeds in 8.2% yield over 23 steps, features two 1,4-syn boron aldol reactions, a Sonogashira coupling, and an α-glycosylation to append the l-evalose sugar moiety.