1225386-90-2Relevant academic research and scientific papers
Indolone derivative with [alpha]-glucosidase inhibitory activity and preparation method and application thereof
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Paragraph 0037-0042; 0065, (2020/05/30)
The invention discloses an indolone derivative with [alpha]-glucosidase inhibitory activity and a preparation method and application thereof. The indolone derivative has a structure as shown in a formula I, in the formula, R is substituted or unsubstituted aryl or heteroaryl. The indolone derivative can be used for preparing compositions, medicines and health-care products for preventing and/or treating diabetes mellitus. According to the invention, a series of 5-fluoroindolone compounds are designed and synthesized by taking a 5-fluoroindolone structure as a parent nucleus through a chemicalsynthesis method; and meanwhile, the related biological activity and structure-activity relationship are deeply discussed, so that a solid theoretical basis is provided for finding and discovering high-efficiency and low-toxicity [alpha]-glucopyranase inhibitor drug lead compounds.
Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation
Ueda, Satoshi,Okada, Takahiro,Nagasawa, Hideko
supporting information; experimental part, p. 2462 - 2464 (2010/08/13)
A strategy involving palladium-catalysed aromatic C-H functionalisation/ intramolecular alkenylation provides a convenient and direct synthesis of 3-alkylideneoxindoles. In the presence of 5 mol% of PdCl2MeCN 2 and AgOCOCF3, a wide variety of N-cinnamoylanilines gave 3-alkylideneoxindoles in moderate to good yield. The Royal Society of Chemistry.
