1225441-65-5

Basic information

• Product Name: 2,2,2-trichloroethyl 2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6-oxo-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-3-yl sulfate
• Synonyms: 2,2,2-trichloroethyl 2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6-oxo-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-3-yl sulfate
• CAS NO: 1225441-65-5
• Molecular Weight: 769.01
• Mol File: 1225441-65-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2,2-trichloroethyl 2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6-oxo-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-3-yl sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trichloroethyl 2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6-oxo-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-3-yl sulfate(1225441-65-5)
• EPA Substance Registry System: 2,2,2-trichloroethyl 2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6-oxo-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-3-yl sulfate(1225441-65-5)

Safety Data

• Hazardous Substances Data: 1225441-65-5(Hazardous Substances Data)

Upstream product

• 764-09-0 chlorosulfuric acid 2,2,2-trichloroethyl ester 
• 1225441-64-4 3-hydroxy-2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 623550-16-3 4-bromo-1-methoxy-2-(methoxymethoxy)benzene 
• 570402-54-9 dimethyl 1-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-bis(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate 
• 570402-52-7 dimethyl 3,4-dihydroxy-1-[2-(3,4-dimethoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate 
• 570402-50-5 dimethyl N-[2-(3,4-dimethoxyphenyl)ethyl]iminodiacetate 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 40914-19-0 3-benzyloxy-4-methoxyphenol 
• 1352336-46-9 2-[4-methoxy-3-(methoxymethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 540463-56-7 2-benzyloxy-1-methoxy-4-(methoxymethoxy)benzene 
• 1225441-52-0 3-benzyloxy-2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 1225441-60-0 3-benzyloxy-8,9-dihydro-2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 

Downstream Products

• 895632-77-6 14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6-oxo-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-3-yl 2,2,2-trichloroethyl sulfate 

Relevant articles and documents

Synthesis, structure-activity relationships, and mechanism of action of anti-HIV-1 lamellarin α 20-sulfate analogues

Lamellarin α and six different types of lamellarin α 20-sulfate analogues were synthesized and their structure-activity relationships were investigated using a single round HIV-1 vector infection assay. All lamellarin sulfates having pentacyclic lamellarin core exhibited anti-HIV-1 activity at a 10 μM concentration range regardless of the number and position of the sulfate group. On the other hand, non-sulfated lamellarin α and ring-opened lamellarin sulfate analogues did not affect HIV-1 vector infection in similar concentrations. The lamellarin sulfates utilized in this study did not exhibit unfavorable cytotoxic effect under the concentrations tested (IC50 > 100 μM). Confocal laser scanning microscopic analysis indicated that hydrophilic lamellarin sulfates were hardly incorporated in the cell. HIV-1 Env-mediated cell-cell fusion was suppressed by lamellarin sulfates. These results suggested that lamellarin sulfates have a novel anti-HIV-1 activity besides the previously reported integrase activity inhibition, possibly at a viral entry step of HIV-1 replication.