1225468-42-7

Basic information

• Product Name: 2-(3,4-dichlorophenyl)-4-(4-ethoxy-3-methoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
• Synonyms: 2-(3,4-dichlorophenyl)-4-(4-ethoxy-3-methoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one
• CAS NO: 1225468-42-7
• Molecular Formula: C₂₀H₁₈Cl₂N₂O₃
• Molecular Weight: 405.27452
• Mol File: 1225468-42-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3,4-dichlorophenyl)-4-(4-ethoxy-3-methoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dichlorophenyl)-4-(4-ethoxy-3-methoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one(1225468-42-7)
• EPA Substance Registry System: 2-(3,4-dichlorophenyl)-4-(4-ethoxy-3-methoxybenzylidene)-5-methyl-2,4-dihydro-3H-pyrazol-3-one(1225468-42-7)

Safety Data

• Hazardous Substances Data: 1225468-42-7(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 13124-18-0 3,4-dichlorophenylhydrazine 

Relevant articles and documents

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists

LBVS of 12480 in-house compounds, followed by HTRF assay, resulted in one nonsteroidal compound (11) with antagonistic activity against FXR (69.01 ± 11.75 μM). On the basis of 11, 26 new derivatives (12a-z) were designed and synthesized accordingly. Five

Microwave-assisted one-pot synthesis of pyrazolone derivatives under solvent-free conditions

An efficient one-pot method to generate structurally diverse and medicinally interesting pyrazolone derivatives in good to excellent yields of 51-98% under microwave irradiation and solvent-free conditions has been developed.