1225468-44-9Relevant articles and documents
Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists
Huang, Huang,Yu, Ying,Gao, Zhenting,Jin, Hui,Yan, Wenzhong,Ma, Ruoqun,Zhu, Jin,Shen, Xu,Jiang, Hualiang,Li, Jian,Li, Chenjing,Xu, Xing,Chen, Lili,Zhang, Yong
, p. 7037 - 7053,17 (2012/12/11)
LBVS of 12480 in-house compounds, followed by HTRF assay, resulted in one nonsteroidal compound (11) with antagonistic activity against FXR (69.01 ± 11.75 μM). On the basis of 11, 26 new derivatives (12a-z) were designed and synthesized accordingly. Five
Microwave-assisted one-pot synthesis of pyrazolone derivatives under solvent-free conditions
Ma, Ruoqun,Zhu, Jin,Liu, Jie,Chen, Lili,Shen, Xu,Jiang, Hualiang,Li, Jian
experimental part, p. 3593 - 3601 (2010/09/11)
An efficient one-pot method to generate structurally diverse and medicinally interesting pyrazolone derivatives in good to excellent yields of 51-98% under microwave irradiation and solvent-free conditions has been developed.