1225468-51-8

Basic information

• Product Name: (Z)-3-(4-(3-methoxy-4-(pentyloxy)benzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
• CAS NO: 1225468-51-8
• Molecular Weight: 422.481
• Mol File: 1225468-51-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-3-(4-(3-methoxy-4-(pentyloxy)benzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(4-(3-methoxy-4-(pentyloxy)benzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid(1225468-51-8)
• EPA Substance Registry System: (Z)-3-(4-(3-methoxy-4-(pentyloxy)benzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid(1225468-51-8)

Safety Data

• Hazardous Substances Data: 1225468-51-8(Hazardous Substances Data)

Upstream product

• 93206-92-9 3-methoxy-4-(pentyloxy)benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 38235-71-1 3-hydrazinobenzoic acid 

Relevant articles and documents

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists

LBVS of 12480 in-house compounds, followed by HTRF assay, resulted in one nonsteroidal compound (11) with antagonistic activity against FXR (69.01 ± 11.75 μM). On the basis of 11, 26 new derivatives (12a-z) were designed and synthesized accordingly. Five

Microwave-assisted one-pot synthesis of pyrazolone derivatives under solvent-free conditions

An efficient one-pot method to generate structurally diverse and medicinally interesting pyrazolone derivatives in good to excellent yields of 51-98% under microwave irradiation and solvent-free conditions has been developed.