122549-26-2

Basic information

• Product Name: (E/Z)-4-CARBOXYMETHYL-5-(4-FLUOROPHENYL)-2-METHYL-PENT-4-EN-3-ONE
• Synonyms: (E/Z)-4-CARBOXYMETHYL-5-(4-FLUOROPHENYL)-2-METHYL-PENT-4-EN-3-ONE;2-[(4-Fluorophenyl)Methylene]-4-Methyl-3-oxo-pentanoic Acid Methyl Ester
• CAS NO: 122549-26-2
• Molecular Formula: C₁₄H₁₅FO₃
• Molecular Weight: 250.27
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 122549-26-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 337.129°C at 760 mmHg
• Flash Point: 152.48°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: (E/Z)-4-CARBOXYMETHYL-5-(4-FLUOROPHENYL)-2-METHYL-PENT-4-EN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (E/Z)-4-CARBOXYMETHYL-5-(4-FLUOROPHENYL)-2-METHYL-PENT-4-EN-3-ONE(122549-26-2)
• EPA Substance Registry System: (E/Z)-4-CARBOXYMETHYL-5-(4-FLUOROPHENYL)-2-METHYL-PENT-4-EN-3-ONE(122549-26-2)

Safety Data

• Hazardous Substances Data: 122549-26-2(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Uses

(E/Z)-4-Carboxymethyl-5-(4-fluorophenyl)-2-methyl-pent-4-en-3-one (cas# 122549-26-2) is a compound useful in organic synthesis.

InChI:InChI=1/C14H15FO3/c1-9(2)13(16)12(14(17)18-3)8-10-4-6-11(15)7-5-10/h4-9H,1-3H3/b12-8+

Upstream product

• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 954153-63-0 C₂₄H₂₇FN₂O₄S 
• 853182-31-7 methyl 4-fluoro-α-(1-oxo-2-methylpropyl)-β-(2-oxocyclohexyl)benzenepropanoate 
• 885100-76-5 methyl 6-(4-fluorophenyl)-4-isopropyl-2-methylthio-1,4-dihydropyrimidine-5-carboxylate 
• 160009-35-8 methyl 4-(4-fluorophenyl)-2-(methylsulfanyl)-6-(propan-2-yl)-pyrimidine-5-carboxylate 
• 954152-77-3 C₁₇H₁₅FN₂O₃ 

Relevant articles and documents

Method for continuously preparing rosuvastatin intermediate by micro-channel modular reaction device

The invention discloses a method for continuously preparing a rosuvastatin intermediate by a micro-channel modular reaction device. The method includes the steps: performing reaction on isopropanol solution of fluorobenzaldehyde and isopropanol solution o

PREPARATION OF ALKYL 4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONY)AMINO]-PYRIMIDINE-5-CARBOXYLATE AND ITS SUBSEQUENT CONVERSION TO N-[4-(4-FLUOROPHENYL)-5-FORMYL-6-ISOPROPYL PYRIMIDIN-2-YL]-N-METHYLMETHANESULFONAMIDE-A KEY INTERMEDIATE IN THE SYNTHESIS OF ROSUVASTATIN

The present invention discloses a novel process to prepare a compound of formula (IIA). By reacting a compound of formula-[D], wherein R1 is C1 to C6 alkyl, preferably R1 is methyl or ethyl, more preferably R1 is methyl ; and R2 is C1 to C8 n-alkyl or branched alkyl, cycloalkyl, phenyl , benzyl or substituted phenyl group, preferably R2 is methyl ; with N-methyl methanesulfonamide and a base, optionally with a salt of N-methyl methanesulfonamide, in suitable solvent(s) , to give a compound of formula (IIA), followed by converting compound of formula (IIA) to a compound for formula -[B], by a known process and finally converting a compound of formula (B) to a compound of formula (II), by a novel process using calcium hypochlorite / TEMPO as an oxidant.