1225538-09-9

Basic information

• Product Name: 5-(4-fluorophenyl)indolin-2-one
• Synonyms: 5-(4-fluorophenyl)indolin-2-one
• CAS NO: 1225538-09-9
• Molecular Weight: 227.238
• Mol File: 1225538-09-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)indolin-2-one(1225538-09-9)
• EPA Substance Registry System: 5-(4-fluorophenyl)indolin-2-one(1225538-09-9)

Safety Data

• Hazardous Substances Data: 1225538-09-9(Hazardous Substances Data)

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 193354-13-1 5-iodo-1,3-dihydro-indol-2-one 
• 20780-76-1 5-iodoisatin 
• 20870-78-4 5-bromo-2-indolin-2-one 

Downstream Products

• 1299028-25-3 1-acetyl-5-(4-fluorophenyl)-1,3-dihydro-2H-indol-2-one 
• 1299028-26-4 1,3,3-triacetyl-5-(4-fluorophenyl)-1,3-dihydro-2H-indol-2-one 
• 1299028-24-2 5-(4-fluorophenyl)-3-(propan-2-ylidene)-1,3-dihydro-2H-indol-2-one 
• 1299028-23-1 N,N'-dibenzyl-5-(4-fluorophenyl)-2-oxo-2,3-dihydro-1H-indole-1,3-dicarboxamide 

Relevant articles and documents

Synthesis, Biological, and Computational Evaluation of Novel 1,3,5-Substituted Indolin-2-one Derivatives as Inhibitors of Src Tyrosine Kinase

Several substituted indolin-2-one derivatives were synthesized and evaluated for their activities against Src kinase. Several compounds showed activity against Src, with IC50 values in the low micromolar range. Among them, compound 2f showed the most significant activity with an IC50 value of 1.02 μM. Molecular docking studies have been performed for evaluation of the binding modes of compound 2f into the Src active site. The docking structure of compound 2f disclosed that the indole NH forms a hydrogen bond with the carbonyl of Met341. These results suggest that our novel compound 2f is a promising compound for the further development of indole-based drugs targeting Src kinase. A novel series of indole-2-one derivatives were synthesized and evaluated for their Src inhibitory activities. Compound 2f was found as the most promising compound with an IC50 value of 1.02 μM. Molecular docking studies were performed to disclose the binding mode for compound 2f.